Abstract
The receptors for the I1-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific alpha chain and a common beta chain (betac). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This review focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions.
MeSH terms
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Animals
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism
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Cell Differentiation / physiology
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Cell Division / physiology
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Cell Survival / physiology
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DNA-Binding Proteins / metabolism
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Granulocyte-Macrophage Colony-Stimulating Factor / metabolism
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Humans
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Interleukin-3 / metabolism
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Interleukin-5 / metabolism*
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Milk Proteins*
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Phosphatidylinositol 3-Kinases / metabolism
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Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / metabolism*
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Receptors, Interleukin-3 / metabolism*
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STAT5 Transcription Factor
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Signal Transduction / physiology
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Trans-Activators / metabolism
Substances
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DNA-Binding Proteins
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Interleukin-3
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Interleukin-5
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Milk Proteins
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Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
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Receptors, Interleukin-3
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STAT5 Transcription Factor
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Trans-Activators
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Granulocyte-Macrophage Colony-Stimulating Factor
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Phosphatidylinositol 3-Kinases
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Calcium-Calmodulin-Dependent Protein Kinases