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Biol Chem. 1998 Aug-Sep;379(8-9):933-7.

Signal transduction via Ras.

Author information

1
Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany.

Abstract

Ras is a major regulator of cell growth. It is a GTP-binding protein that functions as a molecular switch, cycling between the GDP-bound OFF and GTP-bound ON states. In the GTP-bound state it interacts with effector proteins that mediate the biological function. It is found as an oncogene in about 30% of human tumors. Structural and mechanistic studies on Ras and its interaction with effectors and GAP will be discussed in the context of the biology and pathophysiology of this protein.

PMID:
9792425
[Indexed for MEDLINE]

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