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Biochem Biophys Res Commun. 1998 Oct 29;251(3):720-6.

Identification of a fission yeast dynamin-related protein involved in mitochondrial DNA maintenance.

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Institut de Pharmacologie et de Biologie Structurale du CNRS, Université Paul Sabatier, 205, route de Narbonne, Toulouse cedex, 31077, France.


Members of the dynamin-related proteins family have been identified in a wide range of organisms, however their precise functions remain elusive. We have identified a new member of that GTPase family in the fission yeast Schizosaccharomyces pombe. We show that Msp1+ is an essential nuclear gene encoding a 101 kDa protein whose closest homologue is the S. cerevisiae MGM1 gene product. We also report that msp1 conditional loss of function affects the maintenance of mitochondrial DNA and leads to growth arrest associated with respiratory deficiency.

[Indexed for MEDLINE]

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