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J Physiol Paris. 1998 Jun-Aug;92(3-4):205-8.

TrkA antagonists decrease NGF-induced ChAT activity in vitro and modulate cholinergic synaptic number in vivo.

Author information

1
Department of Pharmacology & Therapeutics, McGill University, Montreal, PQ, Canada.

Abstract

Cholinergic neurons are known to respond in vivo to the administration of nerve growth factor (NGF) by a prominent and selective increase of choline acetyl transferase activity and by cholinergic synaptogenesis in the rat brain. By using a synthetic TrkA antagonist we demonstrated that endogenously produced NGF is involved in the continual re-modeling of cholinergic neuronal connections during adulthood, acting through TrkA receptors.

PMID:
9789809
DOI:
10.1016/s0928-4257(98)80011-9
[Indexed for MEDLINE]

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