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Trends Biochem Sci. 1998 Sep;23(9):324-8.

Conservation of gene order: a fingerprint of proteins that physically interact.

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European Molecular Biology Laboratory, Heidelberg, Germany.


A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.

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