Send to

Choose Destination
See comment in PubMed Commons below
Monaldi Arch Chest Dis. 1998 Jun;53(3):337-42.

Invasive mechanical ventilation in exacerbations of chronic obstructive pulmonary disease.

Author information

Division of Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City 66160, USA.


Exacerbations of chronic obstructive pulmonary disease are appropriately treated when severe airflow obstruction does not respond to intensive therapy, including, at times, noninvasive mechanical ventilation. Ventilatory strategies include avoidance of the ventilatory complications of dynamic pulmonary hyperinflation with its resultant intrinsic positive end-expiratory pressure, thereby decreasing the risk of hypotension and barotrauma. Initial ventilator settings should include an expiratory flow rate between 8-10 L.min-1, a tidal volume of 8-10 and a respiratory rate of 11-14 breaths.min-1 as well as an inspiratory flow rate of 100 L.min-1. Further adjustments are made on the basis of gas exchange and pulmonary mechanics. Medical therapies include beta-agonists and corticosteroids.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center