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J Am Acad Child Adolesc Psychiatry. 1998 Oct;37(10):1022-9.

Behavior therapy versus clomipramine for the treatment of obsessive-compulsive disorder in children and adolescents.

Author information

1
Outpatient Department, Reinier de GraafGasthuis, Delft, The Netherlands. E.deHaan@amc.uva.nl

Abstract

OBJECTIVE:

To compare, via a pilot study, the effectiveness of behavior therapy and of drug treatment in children and adolescents with obsessive-compulsive disorder.

METHOD:

Twenty-two children aged between 8 and 18 years were randomly assigned to behavior therapy (n = 12) or open clomipramine (n = 10) in a parallel design lasting 12 weeks. Behavior therapy included exposure and response prevention administered in weekly sessions. The mean dosage of clomipramine was 2.5 mg/kg (range = 1.4-3.3 mg/kg). The main outcome variables were the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) and the Leyton Obsessional Inventory-Child Version (LOI-CV).

RESULTS:

Significant improvement was obtained in both treatment conditions. Behavior therapy produced stronger therapeutic changes than clomipramine on the CY-BOCS (p < .05), whereas on the LOI-CV no significant differences between the results of the two treatments were found. Five of the nine initial nonresponders showed significant changes after extension of treatment for another 12 weeks.

CONCLUSION:

Behavior therapy is shown to be a good alternative for drug treatment and deserves further study in larger samples of children with obsessive-compulsive disorder.

PMID:
9785713
[Indexed for MEDLINE]
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