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Int J Biochem Cell Biol. 1998 Oct;30(10):1075-9.

Interleukin-1.

Author information

1
School of Medical and Surgical Sciences, University Hospital, Queen's Medical Centre, Nottingham, UK. stylianou@nottingham.ac.uk

Abstract

Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades. These modulate a number of transcription factors including NF kappa B, AP1 and CREB each of which regulate a plethora of immediate early genes central to the inflammatory response. Phase I clinical trials of the soluble type I receptor and IRAP indicate that these have potential anti-inflammatory effects.

PMID:
9785472
DOI:
10.1016/s1357-2725(98)00081-8
[Indexed for MEDLINE]

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