Protein interactions implicated in neurotransmitter release

J Physiol Paris. 1998 Apr;92(2):129-33. doi: 10.1016/S0928-4257(98)80150-2.

Abstract

Biochemical evidence indicates that the exocytotic release of neurotransmitters involves both evolutionary conserved membrane proteins, the SNAREs, as well as ubiquitous cytosolic fusion proteins, NSF and SNAPs. We have analyzed the biochemical properties and the physiological effects of these proteins. Our data suggest models how NSF, SNAPs and SNAREs may function in neurotransmitter exocytosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Amino Acid Sequence
  • Animals
  • Carrier Proteins / metabolism
  • Conserved Sequence
  • Evolution, Molecular
  • Exocytosis
  • Membrane Proteins / chemistry*
  • Membrane Proteins / physiology*
  • Models, Molecular
  • Models, Neurological
  • N-Ethylmaleimide-Sensitive Proteins
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / physiology
  • Neurotransmitter Agents / metabolism*
  • SNARE Proteins
  • Synaptosomal-Associated Protein 25
  • Vesicular Transport Proteins*

Substances

  • Carrier Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Neurotransmitter Agents
  • SNARE Proteins
  • Synaptosomal-Associated Protein 25
  • Vesicular Transport Proteins
  • Adenosine Triphosphatases
  • N-Ethylmaleimide-Sensitive Proteins