Format

Send to

Choose Destination
Oncogene. 1998 Sep 17;17(11 Reviews):1475-82.

Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.

Author information

1
Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.

Abstract

The activation of caspases is a final commitment step for apoptosis. It is now evident that signal transduction pathways involving specific protein kinases modulate the apoptotic response. Both pro-apoptotic and anti-apoptotic pathways integrate environmental cues that control the decision to undergo apoptosis. Pro- and anti-apoptotic signal pathways regulate the activation of the caspases. In this review we describe our current understanding of apoptotic signal transduction.

PMID:
9779994
DOI:
10.1038/sj.onc.1202183
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center