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Trends Microbiol. 1998 Sep;6(9):370-8.

The great escape: structure and function of the autotransporter proteins.

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  • 1Dept of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA.


The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an overall unifying structure comprising three functional domains: the amino-terminal leader sequence, the secreted mature protein (passenger domain) and a carboxy-terminal (beta-) domain that forms a beta-barrel pore to allow secretion of the passenger protein. Members of this family have been implicated as important or putative virulence factors in many Gram-negative pathogens.

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