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Trends Microbiol. 1998 Sep;6(9):366-70.

Kinase-phosphatase competition regulates Bacillus subtilis development.

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Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA.


The major regulator of sporulation initiation in Bacillus subtilis is the phosphorelay, a multicomponent signal transduction system. A myriad of signals, both positive and negative, from the environment, cell cycle and metabolism is received and interpreted by the phosphorelay and integrated through the opposing activity of protein kinases and protein aspartate phosphatases to create an extremely sophisticated regulatory network.

[Indexed for MEDLINE]

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