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Trends Microbiol. 1998 Sep;6(9):354-8.

Interdependence of mycobacterial iron regulation, oxidative-stress response and isoniazid resistance.

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Public Health Research Institute, New York, NY 10016, USA.


Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.

[Indexed for MEDLINE]

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