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Am J Surg. 1998 Aug;176(2A Suppl):26S-38S.

Physiology and healing dynamics of chronic cutaneous wounds.

Author information

1
Division of Plastic and Reconstructive Surgery, University of Louisville, Kentucky 40292, USA.

Abstract

In the last few decades, a great deal of progress has been made in understanding the cellular and biochemical interplay that comprises the normal wound healing response. This response is a complex process involving intricate interactions among a variety of different cell types, structural proteins, growth factors, and proteinases. The normal wound repair process consists of three phases--inflammation, proliferation, and remodeling--that occur in a predictable sequence and comprise a series of cellular and biochemical events. A review of the biochemical and physiologic processes that regulate wound healing and the cascade of cellular events that gives rise to the healing process is presented here.

PMID:
9777970
DOI:
10.1016/s0002-9610(98)00183-4
[Indexed for MEDLINE]

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