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J Clin Pathol. 1976 Jul;29(7):634-8.

Sea-blue histiocytosis associated with hyperlipidaemia.

Abstract

A patient with sea-blue histiocytosis in spleen and bone marrow with an accompanying hyperlipidaemia is described. The hyperlipidaemia was due to an increase in "free" cholesterol, lecithin, and triglycerides. Despite these findings lecithin-cholesterol acyl transferase activity was normal. Although the precise biochemical defect was not identified, there was a failure of transport of cholesterol from chylomicrons in vitro. We propose that the sea-blue histiocyte is a marker, in some cases, of abnormal lipid metabolism.

PMID:
977773
PMCID:
PMC476131
[Indexed for MEDLINE]
Free PMC Article
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