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Immunobiology. 1998 Aug;199(2):208-24.

Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin.

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Department of Biochemistry, University of Oxford, UK.


Several proteins have been identified as candidate cell-surface receptors for the complement protein C1q. Some of these also interact with the structurally-related collectin proteins. Previous descriptions of C1q-binding properties of cells, and information on the cellular distribution of candidate receptors suggest that there is more than one physiologically relevant receptor for C1q. Two such candidate receptors, cell-surface calreticulin (also referred to as cC1qR or collectin receptor) and megalin are discussed in this review.

[Indexed for MEDLINE]

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