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Clin Nephrol. 1998 Sep;50(3):194-6.

Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.

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Department of Medicine, Yale University School of Medicine, New Haven, CT 06520-8029, USA.


Indinavir has been described to cause crystalluria and nephrolithiasis in a variable number of treated patients. Acute renal failure, often reversible with discontinuation of the medication, induction of a diuresis and correction of urinary obstruction if present, occurs in a smaller percent of patients. One recent report described renal biopsy findings, indinavir crystals within cellular casts in the collecting tubules, in a patient receiving this antiretroviral agent. We report a second case of a patient with mild renal insufficiency and pyuria following indinavir therapy and describe similar renal biopsy findings.

[Indexed for MEDLINE]

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