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Psychosomatics. 1998 Sep-Oct;39(5):422-30.

Olanzapine in the treatment of delirium.

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Department of Psychiatry, State University of New York (SUNY) Health Science Center at Syracuse 13210, USA.


Delirium is an organic psychiatric syndrome characterized by fluctuating consciousness and impaired cognitive functioning. Eleven delirious patients were treated with olanzapine (dosage mean +/- standard deviation [SD]: 8.2 +/- 3.4 mg qhs), and 11 delirious control patients were treated with haloperidol (dosage mean +/- SD: 5.1 +/- 3.5 mg qhs). Peak response time was similar in both groups. Five of the 11 olanzapine patients showed significant improvement (> 50% score reduction) on the Delirium Rating Scale (DRS) and no patients had side effects, whereas 6 of the 11 control subjects showed improvement on the DRS and 5 had extrapyramidal symptoms or excessive sedation. Olanzapine may be a useful alternative to haloperidol in the treatment of delirium in hospitalized patients.

[Indexed for MEDLINE]

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