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Mol Psychiatry. 1998 Sep;3(5):449-51.

An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms.

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  • 1NHMRC Psychiatric Epidemiology Research Centre, Australian National University, Canberra, Australia.


A functional polymorphism in the regulatory region of the serotonin transporter gene has been reported to be associated with anxiety-related personality traits. We attempted to replicate this finding in an association study involving 759 Caucasians selected from the general Australian population. We found no associations with personality traits (including neuroticism, negative affect and behavioral inhibition), anxiety and depressive symptoms, or alcohol misuse.

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