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Muscle Nerve. 1998 Nov;21(11):1526-9.

Treatment of mononeuropathy multiplex in hepatitis C virus and cryoglobulinemia.

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Department of Neurology, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, New York 10003, USA.


Recent reports advocate alpha-interferon (alpha-Ifn) treatment for mononeuropathy multiplex in hepatitis C virus-associated cryoglobulinemia. We report 2 patients with this disorder to describe two underrecognized treatment outcomes--worsening of polyneuropathy with initiation of alpha-Ifn, in the absence of immunosuppression, and deterioration of liver function with prednisone, despite improvement of polyneuropathy.

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