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FEMS Microbiol Lett. 1998 Sep 15;166(2):213-7.

Activation of a consensus FNR-dependent promoter by DNR of Pseudomonas aeruginosa in response to nitrite.

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Department of Biotechnology, University of Tokyo, Japan.


Expression of the enzymes for anaerobic nitrate respiration of Pseudomonas aeruginosa requires two CRP/FNR-related transcriptional regulators, ANR and DNR. Activity of the consensus CRP- or FNR-dependent promoter in the anr and dnr deficient mutants was investigated. The CRP-dependent promoter was active in the mutant strains. Both regulators could activate the promoter with a consensus FNR-binding motif. DNR-dependent activation was nitrite-dependent, whereas activation by ANR was not, suggesting that only DNR is involved in sensing nitrogen oxides.

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