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Am J Reprod Immunol. 1998 Sep;40(3):145-57.

HLA-G polymorphisms: ethnic differences and implications for potential molecule function.

Author information

1
University of Bonn, Department of Obstetrics and Gynecology, Germany.

Abstract

PROBLEM:

Human leukocyte antigen (HLA)-G is uniquely expressed on extravillous cytotrophoblasts of the placenta and is postulated to be a mediator of maternal immune tolerance. Although it was originally considered to be nonpolymorphic, variations of the HLA-G DNA sequence have been reported, and a limited number of HLA-G alleles been defined.

METHOD OF STUDY:

The HLA-G wild-type sequence was compared with HLA-A2 with regard to the conservation of functionally essential parts of classical HLA-I molecules. HLA-G polymorphisms were analyzed under the aspect of ethnic differences, site, and consequences for postulated molecule functions.

RESULTS:

HLA-G exhibits a high degree of conservation relative to HLA-A2 in functionally relevant sites of HLA-class I molecules. However, polymorphic sites in HLA-G and classical HLA loci are not congruent.

CONCLUSION:

The type and localization of HLA-G polymorphisms suggest that different parts of HLA-G molecule underlie different selective constraints.

PMID:
9764358
[Indexed for MEDLINE]

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