Format

Send to

Choose Destination
Protein Sci. 1998 Sep;7(9):1851-6.

Class-directed structure determination: foundation for a protein structure initiative.

Author information

1
Structural Biology Group, Los Alamos National Laboratory, New Mexico 87545, USA. terwilliger@lanl.gov

Abstract

The recent sequencing of many complete genomes, combined with the development of methods that allow rapid structure determination for many proteins, has changed the way in which protein structure determinations can be approached. One-by-one determinations of individual protein structures will soon be augmented by class-directed structure analyses in which a group of proteins is targeted and structures of representative members are determined and used to represent the entire group. Such a shift in approach would be the foundation for a broad protein structure initiative targeting classes of proteins important for biotechnology and for a fundamental understanding of protein function.

PMID:
9761466
PMCID:
PMC2144164
DOI:
10.1002/pro.5560070901
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center