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Fertil Steril. 1998 Sep;70(3):492-9.

Adverse effects of hydrosalpinx on pregnancy rates after in vitro fertilization-embryo transfer.

Author information

1
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA.

Abstract

OBJECTIVE:

To determine the effect of hydrosalpinx on the establishment of pregnancy after IVF-ET.

DESIGN:

Metaanalysis.

SETTING:

University medical center.

PATIENT(S) AND INTERVENTION(S):

All published reports (n=13) and abstracts (n=10) in English that examined the relation between hydrosalpinx and IVF-ET were included in the analysis. The metaanalysis was performed by first calculating the odds ratios for each trial and then combining them to obtain a pooled estimate of the odds ratio and a 95% confidence interval.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy.

RESULT(S):

A total of 5,569 cycles was reviewed in the group without hydrosalpinx, and a total of 1,144 was reviewed in the group with hydrosalpinx. The clinical pregnancy rate was approximately 50% lower in patients who had hydrosalpinx. Similarly, the implantation rate was decreased by 50%. These effects were observed also in thawed ET cycles. The abortion rate was more than twofold higher in patients who had hydrosalpinx.

CONCLUSION(S):

This metaanalysis suggests that hydrosalpinx is associated with a reduced chance of implantation and an increased risk of pregnancy loss.

PMID:
9757878
[Indexed for MEDLINE]

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