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Trends Biochem Sci. 1998 Aug;23(8):286-90.

A superfamily of proteins that contain the cold-shock domain.

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Biological Laboratories, Harvard University, Cambridge, MA 02138, USA.


Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial domain and appear to function as RNA-chaperones. They have been implicated in various cellular processes, including adaptation to low temperatures, cellular growth, nutrient stress and stationary phase. The discovery of a domain--the cold-shock domain--that shows strikingly high homology and similar RNA-binding properties to CSPs in a growing number of eukaryotic nucleic-acid-binding proteins suggests that these proteins have an ancient origin.

[Indexed for MEDLINE]

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