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Neurosci Lett. 1998 Aug 28;253(1):49-52.

Localization of the neurokinin 1 (NK-1) receptor in the human antrum and duodenum.

Author information

1
Department of Physiology, University of British Columbia, Vancouver, Canada.

Abstract

A newly available antibody to the neurokinin-1 receptor (NK-1r) has made it possible to determine the distribution of the NK-1r receptor in human tissue. In the present study the distribution of the NK-1r and substance P have been determined in the human antrum and duodenum by immunocytochemistry. The NK-1r was present on myenteric and submucosal neurons and nerve fibers of the gastro-enteric nervous system. In addition, the receptor was present on spindle-shaped cells in the circular muscle layer, endothelial cells and a population of mucosal cells. In the submucosal plexus NK-1r immunoreactive neurons were surrounded by substance P containing fibers. These results indicate an extensive cellular expression of the NK-1r in the human antrum and duodenum.

PMID:
9754802
DOI:
10.1016/s0304-3940(98)00618-1
[Indexed for MEDLINE]

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