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Cell Signal. 1998 Jul;10(7):447-55.

The G-protein betagamma complex.

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Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.


The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

[Indexed for MEDLINE]

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