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Cell Signal. 1998 Jul;10(7):447-55.

The G-protein betagamma complex.

Author information

1
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. gautam@morpheus.wustl.edu

Abstract

The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (alpha betagamma) G proteins. Reviewed here is regulation of signal transduction by the betagamma complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse beta and gamma subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

PMID:
9754712
DOI:
10.1016/s0898-6568(98)00006-0
[Indexed for MEDLINE]

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