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Dermatol Surg. 1998 Sep;24(9):1027-31.

Treatment of xanthelasma palpebrarum with bichloracetic acid.

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Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44483, USA.



Although many treatment modalities have been described for xanthelasma palpebrarum, no single technique has emerged as dominant.


Our purpose was to review the various therapeutic modalities for xanthelasma and to assess the efficacy of topical bichloracetic acid.


Thirteen patients with 25 xanthelasma were treated with topical 100% bichloracetic acid. Efficacy was assessed over a follow-up period of 7 months to 10.5 years (average, 64 months).


Eighty-five percent of patients experienced initial complete clearing, and 72% of their lesions have not required retreatment over an average period of 68 months. Recurrences responded well to repeat treatment. Eighty-three percent of recurrent or poorly responsive lesions were associated with high cholesterol. The most resistant patient had four-lid involvement. Excellent cosmetic results and high patient satisfaction were seen.


Topical bichloracetic acid is a viable alternative to other modalities in the management of xanthelasma. Advantages include simplicity, cost-effectiveness, speed, safety, and efficacy.

[Indexed for MEDLINE]

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