Send to

Choose Destination
FEMS Immunol Med Microbiol. 1998 Aug;21(4):283-6.

Macrophage-lymphocyte interactions mediate anti-Burkholderia pseudomallei activity.

Author information

Department of Microbiology and Immunology, James Cook University, Townsville, Australia.


The mechanisms involved in the pathogenesis of melioidosis, caused by the intracellular bacterium Burkholderia pseudomallei, are unclear. C57BL/6 mice are resistant to infection, while BALB/c mice are highly susceptible. Previous studies have demonstrated that peritoneal exudate cell preparations enriched for macrophages are capable of effectively eliminating intracellular pathogens. In this study we present evidence showing that interaction of macrophages with lymphocytes is necessary for efficient anti-B. pseudomallei activity.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center