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Stat Med. 1998 Aug 15-30;17(15-16):1753-65; discussion 1799-800.

Some controversies in planning and analysing multi-centre trials.

Author information

1
Department of Statistical Science, University College London, U.K.

Abstract

It is shown that a rational approach to planning multi-centre trials will lead to an unequal distribution of patients across centres. Consequently different approaches to estimation will yield different estimates. However, some such approaches are not reasonable and it is concluded that multi-centre trials are less problematic than is commonly supposed.

PMID:
9749445
[Indexed for MEDLINE]

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