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Int J Biochem Cell Biol. 1998 Aug;30(8):863-8.

Carnosine, a protective, anti-ageing peptide?

Author information

1
Molecular Biology and Biophysics Group, King's College London, Strand, UK.

Abstract

Carnosine (beta-alanyl-L-histidine) has protective functions additional to anti-oxidant and free-radical scavenging roles. It extends cultured human fibroblast life-span, kills transformed cells, protects cells against aldehydes and an amyloid peptide fragment and inhibits, in vitro, protein glycation (formation of cross-links, carbonyl groups and AGEs) and DNA/protein cross-linking. Carnosine is an aldehyde scavenger, a likely lipofuscin (age pigment) precursor and possible modulator of diabetic complications, atherosclerosis and Alzheimer's disease.

PMID:
9744078
DOI:
10.1016/s1357-2725(98)00060-0
[Indexed for MEDLINE]

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