Send to

Choose Destination
See comment in PubMed Commons below
J Ethnopharmacol. 1998 Sep;62(2):117-22.

Contraceptive and non-estrogenic effects of methanolic extract of Asparagus pubescens root in experimental animals.

Author information

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria.


The methanolic extract of Asparagus pubescens Bak root was investigated for its contraceptive activity in mice, rats and rabbits. The extract dose-dependently (0.5-1.5 g/kg) protected the animals from conception for 4-14 gestational periods in rabbits, rats and mice. It inhibited fetal implantation, as was confirmed by laparotomy on day 10 of pregnancy. The pups showed significant change in weight and length (P < 0.05-0.001) with 1.5 g/kg compared to the control fetal defects. In ovariectomized immature young rats and mice, there was a dose-dependent decrease in uterine wet weight (P < 0.001). The extract did not induce any uterotrophic effects or immature vaginal opening when compared to estrogen treated groups. Its contraceptive effect may in part be due to its anti-implantation and/or a direct effect on the uterus.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center