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Planta Med. 1998 Aug;64(6):577-8.

Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.

Erratum in

  • Planta Med 1998 Dec;64(8):769. Ho C [corrected to Cheong H].


The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property. It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.

[Indexed for MEDLINE]

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