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Curr Biol. 1998 Sep 10;8(18):R636-9.

Cell cycle: oiling the gears of anaphase.

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1
Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94305, USA.

Abstract

The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.

PMID:
9740795
[Indexed for MEDLINE]
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