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Biochim Biophys Acta. 1998 Aug 19;1378(1):F1-19.

The papillomavirus E6 proteins.

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  • 1Department of Dermatology, New England Medical Center, Boston, MA, USA.


Specific types of human papillomaviruses (HPV) are strongly associated with the development of cervical cancer. The E6 gene from cancer-related HPVs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. Cancer-related HPVs E6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. Several additional cellular E6-binding proteins have recently been identified and implicated in playing roles in p53-independent functions of E6.

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