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Mech Dev. 1998 Jul;75(1-2):163-5.

CMIX, a paired-type homeobox gene expressed before and during formation of the avian primitive streak.

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Max-Planck-Institut für biophysikalische Chemie, Abteilung Molekulare Zellbiologie, Am Fassberg, D-37077, Göttingen, Germany.


We cloned a chicken homeobox gene closely related to the Xenopus Mix. 1 gene. CMIX is expressed early in embryogenis in a sickle-shaped area in the posterior zone of the blastoderm. With the beginning of gastrulation, CMIX transcripts are found in the primitive streak primordium, then in the young and medium-sized streak, however not in the mesoderm after its emergence. In the fully-extended streak, CMIX is restricted to its middle, i.e. the prospective ventral mesoderm. CMIX RNA is undetectable by whole-mount in-situ analysis in later stages. We compare CMIX expression to the early pattern of the brachyury gene.

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