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Structure. 1998 Aug 15;6(8):945-9.

HIV gp120: double lock strategy foils host defences.

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Centre d'Immunologie de Marseille-Luminy, Marseille, France.


The recent determination of the structure of a complex formed between the HIV-1 glycoprotein gp120, CD4 and an antibody fragment has revealed new mechanisms for viral evasion of the immune response and shed light on how the virus enters target cells. The results of this work, together with related biochemical studies, may assist in the future design of therapeutic strategies against HIV-1 infection.

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