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Jpn J Cancer Res. 1998 Jul;89(7):691-5.

Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA.

Author information

1
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, School of Medicine, University of Occupational and Environmental Health, Kitakyushu.

Abstract

The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n=70) and non-cancer patient controls (n=15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).

PMID:
9738974
PMCID:
PMC5921888
[Indexed for MEDLINE]
Free PMC Article

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