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FEBS Lett. 1998 Aug 14;433(1-2):1-4.

A novel aspect of calpain activation.

Author information

1
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan. kosuzuyki@iam.u-tokyo.ac.jp

Abstract

Calpain, a Ca2+-dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure-function relationship of calpain and X-ray analysis of its Ca2+-binding domain have revealed hitherto unknown features of the regulation of calpain activity. A novel dissociation/autolysis mechanism for the activation of calpain at the membrane is proposed, which incorporates recent findings from structure-function studies of calpain, and its implications are discussed.

PMID:
9738920
DOI:
10.1016/s0014-5793(98)00856-4
[Indexed for MEDLINE]
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