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Hum Genet. 1998 Jul;103(1):11-21.

MTHFR association with arteriosclerotic vascular disease?

Author information

1
Medical and Community Genetics, Imperial College School of Medicine, Northwick Park and St. Mark's NHS Trust, Harrow, UK.

Abstract

Complex diseases are far more common than diseases that follow simple Mendelian patterns of inheritance. Difficulties are experienced in the designing of experiments to dissect out the contribution of a single allele to a complex phenotype. We review the literature regarding a point mutation in methylenetetrahydrofolate reductase, a candidate gene for susceptibility to vascular diseases.

PMID:
9737770
DOI:
10.1007/s004390050776
[Indexed for MEDLINE]

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