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Trends Neurosci. 1998 Sep;21(9):401-7.

Cellular mechanisms of cerebellar LTD.

Author information

1
Institut des Neurosciences, CNRS-Université Paris VI, France.

Abstract

In the past decade there have been advances in understanding the cellular mechanisms of the long-term depression (LTD) of synaptic transmission at parallel fiber-Purkinje cell synapses in the cerebellum. This review first summarizes current views on mechanisms involved in LTD induction, from activation of voltage-gated Ca2+ channels, of ionotropic (AMPA) and metabotropic (mGluRI) glutamate receptors, to stimulation of protein kinase C and nitric oxide formation. Second, we will focus on recent findings that point towards the involvement of Ca2+ release from internal stores in LTD induction, localize the sources and targets of nitric oxide and indicate a postsynaptic site for LTD expression. Finally, a role for LTD in motor learning is now well supported by recent experiments on transgenic mice.

PMID:
9735948
DOI:
10.1016/s0166-2236(98)01304-6
[Indexed for MEDLINE]

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