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Trends Neurosci. 1998 Sep;21(9):375-82.

The cells and molecules that make a cerebellum.

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Dept of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA.


The molecular underpinnings of cerebellar development are being established through the identification of naturally occurring mutated genes and the knockout of other genes. Sets of genes expressed in the regions of the mes- and metencephalon have been shown to play a crucial role in specifying the cerebellar anlage. Other genes have been shown to be crucial to early granule-cell development, migration of Purkinje and granule cells, and neuron-glia interactions. However, the process of development will ultimately be understood in terms of cellular interactions and the roles that each cell type plays in the assembly of cerebellar structure. One of the most important interactions is between granule and Purkinje cells. This relationship has been shown to be crucial for the control of cell number, migration of neuroblasts and cell differentiation.

[Indexed for MEDLINE]

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