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Am J Clin Nutr. 1998 Sep;68(3):531-7.

Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects.

Author information

1
Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139, USA.

Abstract

BACKGROUND:

Neurobehavioral symptoms have been reported anecdotally with aspartame.

OBJECTIVE:

This study sought to determine whether aspartame can disrupt cognitive, neurophysiologic, or behavioral functioning in normal individuals.

DESIGN:

Forty-eight healthy volunteers completed a randomized, double-blind, placebo-controlled, crossover study. The first month was aspartame free. Subjects then consumed sodas and capsules with placebo, aspartame, or sucrose for 20 d each. Order was randomized and subjects were assigned to either a high- (45 mg x kg body wt(-1) x d(-1)) or low- (15 mg x kg body wt(-1) x d(-1)) dose aspartame group. Neuropsychologic and laboratory testing was done on day 10 of each treatment period to determine possible acute effects and on day 20 for possible chronic effects.

RESULTS:

Plasma phenylalanine concentrations increased significantly during aspartame treatment. Neuropsychologic results; adverse experiences; amino acid, insulin, and glucose values; and electroencephalograms were compared by sex and by treatment. No significant differences were found for any dependent measure.

CONCLUSION:

Large daily doses of aspartame had no effect on neuropsychologic, neurophysiologic, or behavioral functioning in healthy young adults.

PMID:
9734727
DOI:
10.1093/ajcn/68.3.531
[Indexed for MEDLINE]

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