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Nat Struct Biol. 1998 Sep;5(9):787-92.

An atomic model of fimbrin binding to F-actin and its implications for filament crosslinking and regulation.

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The W.M. Keck Institute for Cellular Visualization, Brandeis University, Waltham, Massachusetts 02254, USA.

Erratum in

  • Nat Struct Biol 1998 Oct;5(10):924.


Using a new procedure that combines electron-density correlation with biochemical information, we have fitted the crystal structure of the N-terminal actin-binding domain of human T-fimbrin to helical reconstructions of fimbrin-decorated actin filaments. The map locates the N-terminal calcium-binding domain and identifies actin-binding site residues on the two calponin-homology domains of fimbrin. Based on this map, we propose a model of a fimbrin crosslink in an actin bundle and its regulation by calcium.

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