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Curr Opin Genet Dev. 1998 Aug;8(4):464-71.

The zebrafish organizer.

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Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York 10016, USA.


Signals from the organizer play a crucial role in patterning the vertebrate embryo. Recent molecular analysis of zebrafish mutations has established an essential role for BMP2 and chordin in organizer function and has identified one-eyed pinhead as a novel EGF-like gene involved in prechordal plate and endoderm formation. In addition, embryological studies have suggested that the zebrafish organizer is induced by extraembryonic cues and have defined two novel organizing centers that pattern the nervous system along the anterior-posterior axes.

[Indexed for MEDLINE]

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