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Curr Opin Genet Dev. 1998 Aug;8(4):436-42.

Notch signaling: direct or what?

Author information

1
Department of Biological Chemistry, UCLA School of Medicine 90095-1737, USA. gweinmaster@mednet.ucla.edu

Abstract

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.

PMID:
9729720
DOI:
10.1016/s0959-437x(98)80115-9
[Indexed for MEDLINE]

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