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Curr Opin Genet Dev. 1998 Aug;8(4):419-22.

Specificity in signaling pathways: assembly into multimolecular signaling complexes.

Author information

1
Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093-0649, USA.

Abstract

A critical issue in the field of signal transduction is how signaling molecules are organized into different pathways within the same cell. The importance of assembling signaling molecules into architecturally defined complexes is emerging as an essential cellular strategy to ensure specificity and selectivity of signaling. Scaffold proteins function as the pillars of these transduction complexes, bringing together a diversity of signaling components into defined ultramicrodomains of signaling.

PMID:
9729717
DOI:
10.1016/s0959-437x(98)80112-3
[Indexed for MEDLINE]

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