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Brain Res. 1998 Aug 24;803(1-2):54-60.

Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain.

Author information

1
Department of Pharmacology and Toxicology, Otto-von-Guericke University, Leipziger Str.44, D-39120, Magdeburg, Germany.

Abstract

Cortistatin (CST-14) is a recently discovered endogenous peptide which shares similarity to somatostatin and binds to somatostatin receptors. In this study, we show that CST-14 exhibits anticonvulsive and neuroprotective effects in rats. Injection of rats with kainic acid (KA; 10 mg/kg; i.p.) generated a strong seizure activity which was attenuated by the i.c.v. application of 1 and 10 nmol CST-14 when given 10 min before KA. Moreover, 3 days after KA injection, a marked loss of neurons in cortex and hippocampus of rats was observed which was inhibited by pretreatment with CST-14. An immunohistochemical analysis using specific antibodies revealed that KA reduced immunoactive sst2A and sst3 somatostatin receptors in the hippocampus-an effect which was largely prevented by pretreatment with CST-14. Superfusion of hippocampal slices with CST-14 also reduced the stimulated release of 3H-d-aspartate. We conclude that CST-14 exerts neuroprotective effects by binding to somatostatin receptors which in turn leads to a reduced release of excitotoxic neurotransmitters.

PMID:
9729275
DOI:
10.1016/s0006-8993(98)00609-x
[Indexed for MEDLINE]

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