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Magn Reson Med. 1998 Sep;40(3):454-9.

Ex vivo tissue-type independence in proton-resonance frequency shift MR thermometry.

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Department of Medical Biophysics, University of Toronto, Sunnybrook Health Science Center, Ontario, Canada.


The temperature sensitivity of the proton-resonance frequency (PRF) has proven valuable for the monitoring of MR image-guided thermal coagulation therapy. However, there is significant inconsistency in reported values of the PRF-thermal coefficient, as measured from experiments encompassing a range of in vivo and ex vivo tissue types and experimental conditions. A method of calibrating the temperature dependence of the PRF is described and results are presented that indicate a tissue-type independence. To this end, other possible mechanisms for variations in the PRF-thermal coefficient are suggested, including physiological perturbations and volume magnetic susceptibility effects from geometry and orientation.

[Indexed for MEDLINE]

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