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Australas Radiol. 1998 Aug;42(3):216-8.

Rothmund-Thomson syndrome and tolerance of chemoradiotherapy.

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Royal Adelaide Hospital Cancer Centre, Royal Adelaide Hospital, Australia.


Rothmund-Thomson syndrome (RTS) is a rare disorder with a predisposition for cutaneous and non-cutaneous malignancy. It is speculated that ultraviolet (UV) sensitivity and deficient DNA repair may account for this predisposition and influence the tolerance of chemoradiotherapeutic management. A case is reported of the management of an RTS patient with squamous cell carcinoma of the tongue who demonstrated increased radiosensitivity and tissue intolerance to chemotherapy.

[Indexed for MEDLINE]

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